What is the Mammalian Stress Mechanism?


“There is only one health, but diseases are many. Likewise, there appears to be one fundamental force that heals, although the myriad schools of medicine all have their favorite ways of cajoling it into action.”—Robert O. Becker "The Body Electric"

The mammalian stress mechanism (MSM) is the extracellular physiological mechanism that converts genetic information into embryological development and then maintains mature multicellular structures (tissue repair) and regulates the “internal milieu” that sustains body cells (physiology). Its description is based on published, peer-reviewed research, and is consistent with known science. It is analogous to the coagulation cascade that was described during the era of stress research. 

The MSM consists of the nervous system, blood-borne liver enzyme factors VII, VIII, IX and X, and the vascular endothelium. Combinations of nervous activity and tissue disruption affect the vascular endothelium, which alters the enzymatic interaction of factors VII, VIII, IX and X  to generate thrombin, soluble fibrinand insoluble fibrin. The constantly fluctuating magnitude and location of these products produces positive feedback that focuses MSM activity to enable tissue repair and produces a bewildering blizzard of effects that obscures the relative simplicity of the MSM.

The MSM incorporates a tissue repair mechanism that repairs tissues and a capillary gate mechanism that regulates blood flow in tissues and organs (hemodynamic physiology). The stress-induced activity of each sub-mechanism exaggerates that of the other to generate positive feedback that focuses MSM activity to repair tissues and restore the internal milieu.  Negative feedback (tissue repair, parasympathetic activity) restores resting MSM activity if stresses subside, but disease appears when positive feedback overwhelms negative feedback.

Individual stressors elicit distinctive MSM reactions that distinguish diseases from one another, but most diseases share common manifestations (fever, malaise, weight loss, fatigue, etc.) that reflect MSM hyperactivity. Such hyperactivity explains the relationships of diverse diseases. For example, cancer, hypertension, diabetes and obesity are closely related. Control of MSM hyperactivity can enhance treatments and salvage lives, particularly in life-threatening critical illnesses such as eclampsia, MOFS, ARDS, and cancer. It can also enhance antibiotic potency and penetrance to control stubborn infections. The MSM confers a fresh theory of anesthesia, analgesia, and allostasis that will re-revolutionize surgery.

The MSM is the first stress mechanism to be discovered. Similar stress mechanisms characterize other vertebrate classes. Each adapts to a specific set of environmental circumstances and requires compatible anatomical, behavioral, and physiological characteristics. The MSM thus confers a unified theory of biology that explains embryology, evolution, ethology, intelligence, anatomy, taxonomy, exercise tolerance, food requirements, temperature tolerance, dinosaurs, the Cambrian Explosion, Fight or Flight, and the origin and nature of life as well as physiology, pathology, and stress.  

View a 15 minute slide show that reviews the history of stress theory here

View a 15 minute slide show that explains the shortcomings of conventional physiology theory  here

View a 15 minute slide show that explains MSM operation here

View a 15 minute slide show that explains the interaction of blood enzymes  here

View a 15 minute slide show that explains the function of the vascuar endothelium  here

View a 15 minute slide show that explains the tissue repair mechanism here

The following 15 minute slide shows explain the capillary gate mechanism:

Part VII The Capillary Gate Component http://youtu.be/sE1m6OAMk38

Part VIII The Capillary Gate Mechanism http://youtu.be/cQHZZvtMnvw 

Part IX: Pipe Turbulence https://youtu.be/ghS1BZwgkGU

Part X The Turbulence Mechanism https://www.youtube.com/watch?v=eJSKxq8dlFU&feature=em-upload_owner-smbtn






A simplified diagram of the MSM. The MSM incorporates recent research that clarifies the relationships of stress, nervous activity, tissue disruption,  tissue repair, hemostasis, and hemodynamic physiology.  Sympathetic tone releases VWF from the vascular endothelium to close the capillary gate of the MSM, shown in red, which is analogous to the “intrinsic pathway” of the coagulation cascade. Parasympathetic tone, shown in green, releases nitric oxide (NO) from the vascular endothelium to open the capillary gate. The capillary gate regulates hemodynamic physiology. Tissue damage activates the “tissue repair mechanism,” shown in blue, that is analogous to the “extrinsic pathway” of the coagulation cascade, to enable tissue repair. The tissue repair mechanism regulates the orderly sequence of tissue repair. Thrombin effects are portrayed in yellow. A more detailed diagram of the MSM can be found here.