“There is only one health, but diseases are many. Likewise, there appears to be one fundamental force that heals, although the myriad schools of medicine all have their favorite ways of cajoling it into action.”
—Robert O. Becker
The mammalian stress mechanism(MSM) is the homeostatic, self-limiting extracellular physiological mechanism that enables mammalian multicellular existence. It converts chromosomal genetic information into embryological development and then maintains mature structures and regulates the “internal milieu” that sustains cells within the body.
The MSM is ubiquitous throughout the body. It consists of the nervous system, blood-borne liver enzyme factors VII, VIII, IX and X, and the vascular endothelium. It governs the generation of three products that explain all its effects: thrombin, soluble fibrin, and insoluble fibrin.
The MSM incorporates a tissue repair mechanism that regulates coagulation, inflammation, chemotaxis, mitosis, metabolism, immune activity and apoptosis to repair tissues and a capillary gate mechanism that maintains arterial patency via a turbulence mechanism and regulates cardiac output, cardiac efficiency, tissue perfusion, organ function, blood pressure, and pulse rate.
Combinations of environmental stress induce harmful MSM hyperactivity that appears as disease. Specific stresses produce distinctive MSM hyperactivity that facilitates diagnosis, but all forms of disease are closely related.
The MSM is analogous to the coagulation cascade that was described during the era of stress research but it incorporates fresh information that explains the relationships of coagulation with nervous activity and tissue repair. It is the first stress mechanism to be discovered. Other vertebrate classes possess similar stress mechanisms. Each adapts to a specific set of environmental circumstances and requires compatible anatomical and behavioral characteristics. For example, poikilothermic reptiles thrive in warm climates and are covered with plates that absorb heat. Euthermic mammals evolved from reptiles via a new stress mechanism. They thrive in cold climates and are covered with fur. The MSM thus implies a unified theory of biology that explains evolution, taxonomy, anatomy, ethology, intelligence, emotion, fight or flight, the Cambrian Explosion, and dinosaurs.
A simplified diagram of the “Mammalian Stress Mechanism” (MSM).The MSM is analogous to the coagulation cascade, but it incorporates recent research that clarifies the relationships of stress, nervous activity, tissue disruption, tissue repair, hemostasis, and hemodynamic physiology. Sympathetic tone releases VWF from the vascular endothelium to activate the “capillary gate component” of the MSM, shown in red, which is analogous to the “intrinsic pathway” of the coagulation cascade. Parasympathetic tone, shown in green, releases nitric oxide (NO) from the vascular endothelium to open the capillary gate. Tissue damage activates the “tissue disruption pathway,” shown in blue, that is analogous to the “extrinsic pathway” of the coagulation cascade, to enable tissue repair.
A detailed diagram of the MSM that illustrates how it produces a bewildering blizzard of manifestations that explain physiology, pathology, and stress.
The Coagulation Cascadewas described in the early 1960’s. It explains coagulation as a “cascade” of enzymatic interactions that produces insoluble fibrin, but it fails to explain how the cascade is initiated, regulated, and concluded. It assumes that the sole purpose of coagulation is hemostasis. Conventional “vasoconstriction” theory fails to explain capillary hemostasis, because capillaries lack the ability to contract. The cascade consists of an “intrinsic pathway” consisting of factors VIII and IX, and an “extrinsic pathway” consisting of factor VII and tissue factor. Both pathways interact with factor X in a “final common pathway” to generate thrombin, soluble fibrin, and insoluble fibrin. By Joe D - Own work, CC BY-SA 3.0,https://commons.wikimedia.org/w/index.php?curid=1983833