Mammalian Stress Mechanism

 "It is the function of science to discover the existence of a general reign of order in nature and to find the causes governing this order." ---Dmitri Mendeleev 

The MSM appears complex, but its underlying structure is simple and symmetrical.

Arrows represent the influence (direct and indirect) that one biological function or reaction brings to bear on another. The MSM is analogous to the older coagulation cascade concept, but it combines more recent research information with capillary gate theory and tissue repair theory to explain tissue repair, physiology and pathology as well as coagulation. It thus explains both tissue repair and hemodynamic physiology, which was previously thought impossible.

The capillary gate component (red) corresponds to the intrinsic pathway of the coagulation cascade. The tissue repair component (blue) corresponds to the extrinsic pathway of the coagulation cascade. Both the MSM and the coagulation cascade generate thrombin (orange), plus soluble fibrin and insoluble fibrin. Inhibitory pathways appear in green.  



Term      Meaning

TFPI      Tissue Factor Pathway Inhibitor
ATIII       Stoichiometric ATIII
ATP        Adenosine Tri-Phosphate
SVR       Systemic vascular resistance
CO         Cardiac output
HR         Heart rate
DIC        Disseminated Intravascular Coagulation
HAPE    High-Altitude Pulmonary Edema
ARDS    Adult Respiratory Distress Syndrome
MSOF    Multi-System Organ Failure
ARF       Acute Renal Failure