“Not only will men of science have to grapple with the sciences that deal with man, but—and this is a far more difficult matter—they will have to persuade the world to listen to what they have discovered. If they cannot succeed in this difficult enterprise, man will destroy himself by his halfway cleverness.”

—Bertrand Russell, 1872-1970

The purpose of this website is to introduce the recent discovery of the mammalian stress mechanism (MSM) to  the lay public, explain how it works, and describe its implications.

You won't find this in the news just yet, but countless hours of research toil, test animal torture, and government subsidies have yielded the ultimate objective of medical science: a unified theory of medicine that confers efficient cures for everything from cancer to the common cold; efficient, affordable health care; humane animal research; profitable pharmaceutical progress; priceless professional prestige; a theory of anesthesia that will re-revolutionize surgery; a new era of health, prosperity, and longevity; and a unified theory of biology that may enable humans to alter evolution, with implications that presently reside in the realm of science fiction.

The 1953 discovery of DNA inspired great excitement that is difficult to discern from our present perspective, but it was always obvious that the DNA mechanism by itself explains only how genetic information is stored and replicated. It doesn't explain embryological development, disease, tissue repair, or physiology. Therefore many believed that the stress mechanism postulated by  Hans Selye functions as a "companion mechanism" that converts DNA genetic information into embryological development, and then remains active throughout the remainder of life to repair tissues and regulate physiology. The hyperactivity of such a mechanism would explain disease. Some believed that its discovery would explain the nature of life. The search for the stress mechanism thus became the prevailing paradigm of medical research for more than 30 years, but it was abandoned after it failed to find any clue of any mechanism that could explain any aspect of Selye's theory, and Selye's ideas were abandoned and mostly forgotten.

Another 30 years of fresh information from unrelated research has belatedly enabled the discovery of the  "mammalian stress mechanism" (MSM) that Selye predicted. It explains and confirms Selye's theory, which is now poised to resume its role as the prevailing paradigm of medical research, and revolutionize medicine. 

The MSM is the first stress mechanism to be identified. It is the missing cog in the machinery of mammalian life. Its discovery represents the most important and exciting advance in medical and biological theory in a lifetime. Whereas DNA by itself only facilitates criminal investigations, the MSM complements and extends the meaning of DNA, and confers life-saving medical treatments.

The hallmark of powerful theory is its ability to explain disparate phenomena. Stress theory exceeds the bounds of medicine and confers a unified theory of biology that explains the origin of life, embryology, evolution, ethology, intelligence, anatomy, taxonomy, the Cambrian explosion, and dinosaurs. Advancing computer science, guided by stress theory, will soon enable a complete understanding of the genetic code and enable humans to alter evolution, with implications that reside in the realm of science fiction. 

Despite its promise, stress theory won't be restored without the help of political reform. The MSM is complex, counterintuitive and at odds with entrenched medical dogma. Powerful commercial interests have imposed an iron curtain of misinformation that has mired medicine in a dark age that will one day be remembered for suffering and superstition, much as we recall leeches and witchcraft. Proven principles are abandoned while politics and propaganda promote perverted principles and poisonous pharmaceuticals for the sake of profits at the price of public health, while Cancer, chronic disease, and critical illnesses increasingly afflict rich and poor alike. 

A book entitled "Recent advances in the stress theory of Hans Selye" is now in the hands of its publisher. Those interested may write to the author at lewis_coleman@yahoo.com. 

Slide shows that explain the mammalian stress mechanism may be found here.

Free downloads of published papers can be found here

"All truth passes through three stages. First, it is ridiculed, second it is violently opposed, and third, it is accepted as self-evident."
Arthur Schopenhauer, Philosopher, 1788-1860


Lewis S. Coleman, MD DABA
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